Translational Physiology Circulating levels of cytochrome c after resuscitation from cardiac arrest: a marker of mitochondrial injury and predictor of survival
نویسندگان
چکیده
Jeejabai Radhakrishnan, Sufen Wang, Iyad M. Ayoub, Julieta D. Kolarova, Rita F. Levine, and Raúl J. Gazmuri Division of Critical Care Medicine, Department of Medicine, and Department of Physiology and Biophysics, and Department of Microbiology and Immunology, Rosalind Franklin University of Medicine and Science, and Section of Critical Care Medicine, Medical Service, North Chicago Veterans Affairs Medical Center, North Chicago, Illinois
منابع مشابه
Circulating levels of cytochrome c after resuscitation from cardiac arrest: a marker of mitochondrial injury and predictor of survival.
Ca(2+) overload and reactive oxygen species can injure mitochondria during ischemia and reperfusion. We hypothesized that mitochondrial injury occurs during cardiac resuscitation, causing release of cytochrome c to the cytosol and bloodstream while activating apoptotic pathways. Plasma cytochrome c was measured using reverse-phase HPLC and Western immunoblotting in rats subjected to 4 or 8 min ...
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